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InterferenceMRI Resource Directory:
 - UltraSound Physics -
 
Interference is the interplay of two or more waveforms. When two or more waves with equal frequency and wavelength interfere, a new wave is created whose amplitude at any point in time and space is the sum of the amplitudes of the original waves at the same point in time and space. Constructive interference occurs when two waves of equal frequency are in phase. The amplitudes will always be in the same direction, and the waves will combine to produce a stronger one. Two equally strong waves with the same amplitude that are 180° out of phase will cancel each other out.
See also Interference Artifact.
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Interference ArtifactInfoSheet: - Artifacts - 
Intro, 
Artifacts, 
ReductionMRI Resource Directory:
 - Artifacts -
 
Interference artifacts occur if decreasing of the echo amplitude is not exponential with penetration depth caused by inhomogeneous tissue layers and fluid or air-filled regions. If ultrasound waves have opposite phases, i.e. if the phase difference is 180°, their amplitudes will always be in opposite directions and their sum is a weaker wave. This is destructive interference and artifacts occur.
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Alliance Pharmaceutical Corp.MRI Resource Directory:
 - Manufacturers -
 
www.allp.htm

California-based research and development company. Alliance Pharmaceutical Corporation. The principal activities of the Company is identifying, designing, and developing novel medical products. The Company is engaged in development of scientific discoveries into medical products and licensing these products to multinational pharmaceutical companies in exchange for fixed payments and royalty or profit sharing payments. The Company has developed three innovative products through initial clinical (human) trials. The products are Oxygent™, Liquivent and Imavist™. The Company's strategy is to identify potential new medical products though its own efforts and scientific collaborations with researchers and clinicians in universities and medical centers. In Dec 2000 the company acquired Molecular Biosystems Inc a developer of intravenous ultrasound contrast agent for the heart.

"September 20, 2001 Alliance Pharmaceutical Corp. announced that it has won a favorable Final Judgment from the United States Patent and Trademark Office's Board of Patent Appeals and Interferences regarding claims in U.S. Patent No. 5,558,854, which is owned by Nycomed Imaging, AS. The Final Judgment determined that claims made in the Nycomed patent with respect to "microbubbles" that contain perfluorohexane filling gas are invalid and are therefore unpatentable."

Ultrasound Related Product Lines:
Contrast Agents:
TRADE NAME FOR SALE FOR SALE /
DEVELOPMENT
DEVELOPMENT
Imagent®

Contact Information:
MAIL Alliance Pharmaceutical Corp.
6175 Lusk Blvd.
San Diego, CA 92121
USA
PHONE +1-858-410-5200
FAX +1-858-410-5161
E-MAIL corpcom@allp.com
ONLINE www.allp.com
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 Further Reading:
  News & More:
IMCOR Pharmaceutical Co., Alliance Pharmaceutical Corp., Molecular Biosystems, Inc. and GE Healthcare Ltd., Inc. Enter Into Cross-Licensing Agreement for Ultrasound Contrast PatentsOpen this link in a new window
   by www.prnewswire.com    
Huygens PrincipleMRI Resource Directory:
 - UltraSound Physics -
 
Huygens principle states that an expanding sphere of waves behaves as if each point on the wave front were a new source of radiation of the same frequency and phase. The principle explains how a flat ultrasound transducer can transmit a narrow ultrasound beam, which in the near field is confined to the dimensions of the transducer surface.
Spherical wavelets are emitted from numerous point sources on the transducer surface. They interfere to form a narrow, slightly converging beam of ultrasound in the near field. The wavefronts in the beam are nearly parallel. A precondition for this interference is that the transducer surface is much larger than the ultrasound wavelength.
See also Interference Artifact.
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 Further Reading:
  Basics:
Reflection and Refraction of Waves (Explanation by Huygens' Principle)Open this link in a new window
   by www.sciencejoywagon.com    
  News & More:
Transmission Line Matrix (TLM) modelling of medical ultrasound(.pdf)Open this link in a new window
   by www.era.lib.ed.ac.uk    
Linear Array TransducerInfoSheet: Probes/Transducers
Intro,
Probes, 
TransducersMRI Resource Directory:
 - Probes Transducers -
 
Linear array transducer elements are rectangular and arranged in a line. Linear array probes are described by the radius of width in mm. A linear array transducer can have up to 512 elements spaced over 75-120 mm. The beam produced by such a narrow element will diverge rapidly after the wave travels only a few millimeters. The smaller the face of the transducer, the more divergent is the beam. This would result in poor lateral resolution due to beam divergence and low sensitivity due to the small element size.
In order to overcome this, adjacent elements are pulsed simultaneously (typically 8 to 16; or more in wide-aperture designs). In a subgroup of x elements, the inner elements pulse delayed with respect to the outer elements. The interference of the x small divergent wavelets produces a focused beam. The delay time determines the depth of focus for the transmitted beam and can be changed during scanning.
Linear arrays are usually cheaper than sector scanners but have greater skin contact and therefore make it difficult to reach organs between ribs such as the heart. One-dimensional linear array transducers may have dynamic, electronic focusing providing a narrow ultrasound beam in the image plane. In the z-plane (elevation plane - perpendicular to the image plane) focusing may be provided by an acoustic lens with a fixed focal zone.
Rectangular or matrix transducers with unequal rows of transducer elements are two-dimensional (2D), but they are termed 1.5D, because the number of rows is much less than the number of columns. These transducers provide dynamic, electronic focusing even in the z-plane.
See also Rectangular Array Transducer.
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 Further Reading:
  Basics:
Ultrasound Physics Main differences between Ultrasound and X-rays, Velocity of sound in some Biological MaterialsOpen this link in a new window
   by www.drgdiaz.com    
  News & More:
Ultrasonic Testing Using Phased ArraysOpen this link in a new window
   by www.ndt.net    
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