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 'MRX 115' 
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MRX 115InfoSheet: - Contrast Agents - Intro, Historical Development, Microbubbles, etc.MRI Resource Directory: - Contrast Agents -
 
MRX 115 is a liposome based microbubble formulation and has been demonstrated as effective for cardiac blood pool imaging, Doppler enhancement and potentially myocardial perfusion imaging.
MRX 115 is based upon the demand for a stable, robust blood pool ultrasound contrast agents, also called DMP 115 or Aerosomes? (ImaRx LLC) and now Definity®.
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Acoustically Active LipospheresMRI Resource Directory: - Contrast Agents -
 
(AALs) Acoustically active lipospheres and ultrasound are under development to deliver bioactive molecules to the vascular endothelium. The AALs are similar to both ultrasound contrast agents and drug-delivering liposomes. They can carry bioactive substances using biologically inert shells and deliver those substances when disrupted by ultrasound.
The lipospheres consist of a small gas microbubble surrounded by a thick oil shell and are enclosed by an outermost lipid layer. The gas bubble contained in these vehicles makes them acoustically active, similar to ultrasound contrast agents. Acoustically active lipospheres can be nondestructively deflected using ultrasound radiation force, and fragmented with high intensity ultrasound pulses. Their lipid-oil complex can carry bioactive substances at high concentrations. An optimized sequence of ultrasound pulses can deflect the AALs toward a vessel wall then disrupt them, painting their contents across the vascular endothelium.
See also Filling Gas, and MRX 115.
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 Further Reading:
  Basics:
A Method for Radiation-Force Localized DrugDelivery Using Gas-Filled Lipospheres(.pdf)Open this link in a new window
Wednesday, 7 July 2004   by www.ncbi.nlm.nih.gov    
  News & More:
Radiation-Force Assisted Targeting Facilitates Ultrasonic Molecular ImagingOpen this link in a new window
Sunday, 4 July 2004   by www.bme.ucdavis.edu    
Bio-effects of ultrasound contrast agents in daily clinical practice: fact or fiction?(.pdf)Open this link in a new window
Monday, 30 April 2007   by eurheartj.oxfordjournals.or    
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Definity®InfoSheet: - Contrast Agents - Intro, Historical Development, Microbubbles, etc.MRI Resource Directory: - Contrast Agents -
 
www.definityimaging.com/newsroom/newsroom/factsheet.asp

From Bristol-Myers Squibb Medical Imaging Inc.
Activated DEFINITY® Injectable Suspension is indicated for use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. The perflutren lipid microspheres exhibit lower acoustic impedance than blood and enhance the intrinsic backscatter of blood.
Echocardiography with Definity produced more detailed images of the heart in difficult-to-image patients versus echocardiography alone, and images obtained with the contrast agent provided a more accurate assessment of segmental wall motion compared with unenhanced images.
See also Coherent Contrast Imaging.

In August 2001 DuPont Pharmaceuticals Company received FDA approval.

Drug Information and Specification:
RESEARCH NAME DMP 115, MRX 115
DEVELOPER Bristol-Myers Squibb Medical Imaging, Inc.
INDICATION -
DEVELOPMENT STAGE		 LV, echocardiography
for sale
APPLICATION Intravenous
TYPE Microbubbles
SHELL Lipids:DPPA, DPPC, MPEG5000 DPPE
CHARGE Negative
GAS Octafluoropropane
MICROBUBBLE SIZE 98% < 10µm
PRESENTATION Package contains four 2mL clear glass single-use vials.
STORAGE Refrigerate 2–8°C
PREPARATION Activate through Vialmix agitation
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

Distribution Information:
TERRITORY DISTRIBUTOR
USA, EU Bristol-Myers Squibb Medical Imaging, Inc.

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 Further Reading:
  Basics:
DuPont Receives FDA Clearance for New Contrast Agent for EchocardiographyOpen this link in a new window
Wednesday, 8 August 2001   by www.appliedradiology.com    
Definity Prescribing Information(.pdf)Open this link in a new window
Wednesday, 1 January 2003   by www.definityimaging.com    
Definity Product DescriptionOpen this link in a new window
  News & More:
CONTRAST ECHOCARDIOGRAPHY: NEW AGENTSOpen this link in a new window
   by eurheartj.oxfordjournals.org    
molecular imaging using ultrasoundOpen this link in a new window
   by www.bme.unc.edu    
American Society of Echocardiography Consensus Statement on the Clinical Applications of Ultrasonic Contrast Agents in EchocardiographyOpen this link in a new window
November 2008   by www.asecho.org    
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 [last update: 2010-09-07 06:10:53]