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 'PESDA' 
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PESDAInfoSheet: - Contrast Agents - Intro, Historical Development, Microbubbles, etc.MRI Resource Directory: - Contrast Agents -
 
(Perfluorocarbon exposed sonicated dextrose albumin) PESDA are sonicated dextrose albumin microbubbles containing decafluorobutane gas. PESDA is a sonicated self made contrast agent and not a commercial product.
PESDA microbubbles can be used as a blood pool contrast agent in echocardiography to improve the detection of myocardial perfusion abnormalities.

Drug Information and Specification:
RESEARCH NAME -
DEVELOPER -
INDICATION -
DEVELOPMENT STAGE		 myocardial perfusion
APPLICATION Intravenous injection
TYPE Microbubble
SHELL Albumin / dextrose
CHARGE -
GAS Decafluorobutane
MICROBUBBLE SIZE Mean: 4.7 ± 0.2 mm
PREPARATION -
DO NOT RELY ON THE INFORMATION PROVIDED HERE, THEY ARE NOT A SUBSTITUTE FOR THE ACCOMPANYING PACKAGE INSERT!

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 Further Reading:
  Basics:
Optimization of ultrasound-mediated gene transfer: comparison of contrast agents and ultrasound modalities1Open this link in a new window
Sunday, 27 July 2003   by eurheartj.oxfordjournals.org    
  News & More:
Transient Myocardial Contrast After Initial Exposure to Diagnostic Ultrasound Pressures With Minute Doses of Intravenously Injected MicrobubblesOpen this link in a new window
   by circ.ahajournals.org    
PerfluorochemicalsMRI Resource Directory: - Contrast Agents -
 
Perfluorochemicals are used as microbubble filling gases because of their low solubility in blood and high vapor pressure. Various types of perfluorochemical gases like perfluorocarbon, perfluorobutane, perfluoropropane, and perfluorohexane are used to substitute the air in microbubbles to improve the stability and plasma longevity of the agents. Perfluorocarbons are liquids at room temperature but gas at body temperature. The large molecules of perfluorocarbons have slow diffusion and solubility which increase the enhancement time of the ultrasound contrast agent as compared to air.
See also Filling Gas, and PESDA.
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 Further Reading:
  Basics:
Science to Practice Which US Microbubble Contrast Agent Is Best for Gene Therapy?Open this link in a new window
   by radiology.rsna.org    
  News & More:
molecular imaging using ultrasoundOpen this link in a new window
   by www.bme.unc.edu    
The role of ultrasound in molecular imaging(.pdf)Open this link in a new window
2003   by bjr.birjournals.org    
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