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 'Ultrasound Contrast Agent Safety' 
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Result : Searchterm 'Ultrasound Contrast Agent Safety' found in 1 term [] and 4 definitions [], (+ 7 Boolean[] results)
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Ultrasound Contrast Agent SafetyInfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
The various gas microbubble contrast media are generally safe with low toxicity in humans. The tolerance of these agents is much higher than that of most x-ray agents, a reflection perhaps of the higher expectation of safety and convenience for ultrasound.
Extensive preclinical and clinical trials have demonstrated an excellent ultrasound contrast agent safety profile, the main side effect being a mild and transient local discomfort at the injection site which results from the high osmolality of these agents. Each contrast agent has its own profile of adverse effects, but all have been trivial thus far.
See also Ultrasonic Contrast Agents.
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Contrast Harmonic ImagingInfoSheet: - Modes - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:<br> - Modes -
 
(CHI) Contrast harmonic imaging is an ultrasound technique to improve the measurement of blood perfusion or capillary blood flow. Based on the nonlinear properties of contrast agents, CHI transmits at the fundamental frequency but receives at the second harmonic. Contrast enhanced echo signals contain significant energy components at higher harmonics (bubbles acts as harmonic oscillators), while tissue echoes do not. Caused by that contrast signal can be separated from tissue echoes by the characteristic signal.
In combination with the pulse inversion technique, CHI promises very high contrast agent sensitivity with high spatial resolution.
See also Ultrasound Contrast Agent Safety and Hemoglobin.
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 Further Reading:
  Basics:
Harmonic Imaging of the Human Brain : Visualization of Brain Perfusion With Ultrasound(.pdf)Open this link in a new window
   by stroke.ahajournals.org    
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Contrast Pulse SequencingInfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.InfoSheet: - Modes - 
Intro, 
Overview, 
Types of, 
etc.MRI Resource Directory:<br> - Modes -
 
(CPS) Contrast pulse sequencing is a technique to exploit contrast agent properties with series of three pulses that differ in phase and amplitude. CPS allows bubble specific imaging with non-linear fundamental and higher order harmonics, low MI, and extremely high microbubble-to-tissue background ratio.
See also Ultrasound Contrast Agent Safety.
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Searchterm 'Ultrasound Contrast Agent Safety' was also found in the following service: 
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Ultrasonic Contrast AgentsMRI Resource Directory:<br> - Contrast Agents -
 
(UCA / USCA) Ultrasonic contrast agents, also called ultrasound contrast agents, are encapsulated bubbles on the order of 1?10 µm in diameter. These gas bubbles are injected into the blood stream in order to increase blood/ tissue contrast during an ultrasonogram. These microbubbles are filled with air or a gas with a lower solubility in blood than air, such as perfluorochemicals. The microbubble shell consists of albumin, phospholipid, or other material and encapsulates the gas core. Due to this construction, ultrasonic contrast agents are highly compressible, and have a high echogenicity.
See also Ultrasound Contrast Agent Safety.
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• View the news results for 'Ultrasonic Contrast Agents' (1).



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Ultrasound Contrast AgentsInfoSheet: - Contrast Agents - 
Intro, 
Historical Development, 
Microbubbles,
etc.MRI Resource Directory:<br> - Contrast Agents -
 
(UCA / USCA) Ultrasonography is the most commonly performed diagnostic imaging procedure. The introduction of sonographic contrast media into routine practice modifies the use of ultrasound in a variety of clinical applications. USCAs consist of microbubbles filled with air or gases and can be classified according to their pharmacokinetics. Among the blood pool agents, transpulmonary ultrasound contrast agents offer higher diagnostic potential compared to agents that cannot pass the pulmonary capillary bed after a peripheral intravenous injection. In addition to their vascular phase, some USCAs can exhibit a tissue- or organ-specific phase.
The sonogram image quality is improved either by decreasing the reflectivity of the undesired interfaces or by increasing the backscattered echoes from the desired regions.

Different types of ultrasound contrast agents:
point tissue contrast agents;
point contrast agents for vascular enhancement;
point agents for targeted contrast imaging.
Ultrasound contrast agents act as echo-enhancers, because of the high different acoustic impedance at the interface between gas and blood. The enhanced echo intensity is proportional to the change in acoustical impedance as the sound beam crosses from the blood to the gas in the bubbles.

The ideal qualities of an ultrasound contrast agent:
point high echogenicity;
point low attenuation;
point low blood solubility;
point low diffusivity;
point ability to pass through the pulmonary capillary bed;
point lack of biological effects with repeat doses.
A typical ultrasound contrast agent consists of a thin flexible or rigid shell composed of albumin, lipid, or polymer confining a gas such as nitrogen, or a perfluorocarbon. The choice of the microbubble shell and gas has an important influence on the properties of the agent.
Current generations of microbubbles have a diameter from 1 µm to 5 µm. The success of these agents is mostly dependent on the small size and on the stability of their shell, which allows passage of the microbubbles through the pulmonary circulation. Microbubbles must be made smaller than the diameter of capillaries or they would embolize and be ineffective and perhaps even dangerous.
The reflectivity of these microbubbles is proportional to the fourth power of a particle diameter but also directly proportional to the concentration of the contrast agent particles themselves.
Ultrasound contrast agents produce unique acoustic signatures that allow to separate their signal from tissue echoes and to depict whether they are moving or stationary. This enables the detection of capillary flow and of targeted microbubbles that are retained in tissues such as normal liver.
The new generation of contrast media is characterized by prolonged persistence in the vascular bed which provides consistent enhancement of the arterial Doppler signal. Contrast agents make it also possible to perform dynamic and perfusion studies. Targeted contrast imaging agents are for example taken up by the phagocytic cell systems and thus have liver//spleen specific effects.
See also Ultrasound Contrast Agent Safety, Adverse Reaction, Tissue-Specific Ultrasound Contrast Agent, and Bubble Specific Imaging.
Radiology-tip.comContrast Agents
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Radiology-tip.comContrast Agents
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• View the news results for 'Ultrasound Contrast Agents' (2).



 Further Reading:
  Basics:
Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS)Open this link in a new window
2008   by www.efsumb.org    
Science to Practice: Blood Flow Quantification with Contrast-enhanced USOpen this link in a new window
   by radiology.rsna.org    
  News & More:
More stable contrast media expand the ultrasound spectrumOpen this link in a new window
   by www.european-hospital.com    
Modeling and Characterization of Ultrasound Contrast AgentsOpen this link in a new window
   by home.online.no    
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